Autoit click on button which is on Frame Autoit click on button which is on Frame This is working code for Eset Gui(version 10.1.2050.0). For going to : Setup ==> Advanced Setup==> Update ==> Profiles ==> Updates ==> Modules Updates #RequireAdmin AutoItSetOption("MouseCoordMode", 0) Run("C:\Program Files\ESET\ESET Security\egui.exe") Sleep(500) WinWait('ESET Endpoint Antivirus') WinActivate('ESET Endpoint Antivirus') MouseClick('primary', 77, 216,2) Sleep(500) MouseClick('primary', 943, 649,2) WinWait('Advanced setup - ESET Endpoint Antivirus') MouseClick('primary', 42, 201,2) Sleep(500) MouseMove(272,103,2) MouseClick('primary') Sleep(500) ConsoleWrite("Hello World" & @CRLF) ConsoleWrite("dddd" & @CRLF) MouseClick('primary',288,157) MouseClick('primary',302,287) MouseClick('primary',669,528)